One of the major challenges in communications system design, is successfully driving the desired signal into the analog to digital converter. The examples shown here help to illustrate the benefits of differential signal chains versus single-ended signal chains. The three major blocks shown here are the driver amplifier, the anti-aliasing filter, and the analog-to-digital converter. Adequate fidelity for signal detection requires proper component selection and implementation of the interface. Reviewed here are two examples, one-single ended and one differential. The goal is to capture the blue portion of the signal transmission on the left hand side. It is a small signal in the presence of other, larger, interfering signals. To capture it, it is necessary to consider noise, dynamic range, and other factors specific to the ADC requirements. This is all necessary to extract only the signal of interest and deliver it to the ADC. This receiver signal is shown at the right; it has been amplified and the blockers have been removed, leaving only the desired portion of the signal, shown in blue.